Global Characterization of Commercial Generation 0-7 Poly(amidoamine) Dendrimers: Challenges and Opportunities for Analysis.

ABSTRACT: PAMAMs make up the most ubiquitous family of dendrimers in use today, with their NH₂ surface functionality rendering them an excellent choice for several valuable applications. However, impurities introduced during synthesis and their surface functionality present unique challenges for analysis. In this work, we discuss and review the applicability of a range of analytical techniques and present methodologies to analyze PAMAM dendrimers from generation 0-7, to extract both chemical and size-based information, through these data, we clearly show how molecular weight and size grow through the generations. Additionally, we show how the shape factor changes from close to 1 in low generations, indicating a majority of mass in the shell of the system, to values around 0.75, indicating

SUBMITTER: Tooley O 

PROVIDER: S-EPMC12529379 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature