A Silver-Copper-Aluminum Layered Double Hydroxide Sensor for Sensitive Determination of Anticancer Agent Afatinib in Bulk and Biological Fluids.

ABSTRACT: Afatinib (AFA), a powerful tyrosine kinase inhibitor, is an FDA-approved drug used to treat advanced nonsmall cell lung cancer (NSCLC) with certain EGFR mutations. As the first irreversible EGFR inhibitor approved for the treatment of lung cancer, it plays a key role in blocking EGFR signaling, making it a significant therapy in targeted cancer treatment. This study presents a pioneering electrochemical approach for determining AFA, a clinically significant anticancer agent, utilizing a novel sensor based on a trimetallic nanocomposite, silver-copper-aluminum layered double hydroxide (AgCuAl-LDH). The sensor was fabricated through a facile, cost-effective hydrothermal synthesis method, resulting in a robust and highly conductive nanomaterial. Structural and morphological characterization v

SUBMITTER: Gabiam EN 

PROVIDER: S-EPMC12529382 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature