Design, Synthesis, <i>In Vitro</i> Evaluation, Multitargeted Molecular Docking, and <i>In Silico</i> Analysis of Some Azo-Linked 1,3,4-Thiadiazole and 1,2,4-Triazole Heterocyclic Hybrids as Potent Antitubercular Agents.

ABSTRACT: The swift emergence of multidrug- and highly drug-resistant strains of Mycobacterium tuberculosis (Mtb) makes it essential to develop new agents with varied chemical structures and multitarget mechanisms of action. In the current investigation, we have designed and synthesized 24 novel heterocyclic ring-substituted 1,3,4-thiadiazole (5a-l) and 1,2,4-triazole (6a-l) hybrids to be tested against the H37RV strain of M. tuberculosis. Compounds 5b, 5d, 5e, 5f, 6b, 6c, 6d, and 6f showed good to moderate effectiveness against tuberculosis, with minimum inhibitory concentration (MIC) values ranging from 4 to 64 μg/mL. Compounds 5b and 6b display an MIC value of 4 μg/mL, suggesting significant antitubercular potential and warranting further exploration as effective antitubercular agen

SUBMITTER: Panigrahi D 

PROVIDER: S-EPMC12529389 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature