ESBL-producing <i>Klebsiella pneumoniae</i> gut colonisation and subsequent health-care associated bacteraemia in preterm newborns: a descriptive cohort with nested case-control study.

ABSTRACT: This descriptive and exploratory observational case series examined intestinal colonisation and subsequent bacteraemia due to ESBL-producing Klebsiella pneumoniae (ESBL-Kp) in preterm neonates in Morocco. Prospective bacteriological cultures and antibiotic susceptibility testing were supported by phenotypic methods, including Brilliance ESBL Agar and the NG-Test CARBA-5 assay, for the rapid detection of ESBL and carbapenemase producers. Molecular analysis using PCR was also undertaken to identify specific resistance genes. A total of 567 rectal swabs were collected from 339 preterm neonates, yielding 293 K. pneumoniae isolates. ESBL-producing strains were identified in 53.6% of the neonates (182/339). Detected resistance genes included blaSHV (26.3%), bla

SUBMITTER: Benboubker M 

PROVIDER: S-EPMC12529433 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature