Vitamin D may influence disease course in PIMS-TS/MIS-C: An observational cohort study.

ABSTRACT:

Background

Pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) remains an enigmatic disease process, with phenotypic similarities to Kawasaki disease, although many patients present with transient cardiac dysfunction. Biomarkers help validate diagnosis, but the correlation of biomarkers to disease severity or prognosis is poorly understood.

Design

We retrospectively reviewed PIMS-TS patients treated in Oxford between May 2020 and May 2022. Data on demographics, presenting features, biochemical markers, treatment, and outcomes were reviewed, and patients with/without the need for vasoactive medications were compared.

Results

We identified 63 patients, median age 10.3 years (range 1.2-15.2 years). Where tested, 51/54 (94.4%) were

SUBMITTER: Charlesworth JEG 

PROVIDER: S-EPMC12529462 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature