Mildly elevated liver lipid content is characterised by reduced insulin sensitivity.

ABSTRACT:

Background & aims

Recently, a new cut-off of ≤1.85% was proposed for normal liver lipid content based on a large population trial. In that study, people having liver lipid between 1.86% and the currently used magnetic resonance spectroscopy-specific upper limit of 5.56% had lower insulin sensitivity (higher homeostatic model assessment for insulin resistance [HOMA-IR]) when compared with people with ≤1.85% of liver lipid. We aimed to build upon these findings by evaluating differences in tissue-specific insulin sensitivity between individuals having low (LL; ≤1.85%) or mildly elevated (MEL; >1.85% and ≤5.56%) liver lipids.

Methods

Combining data from previous studies, 202 White European individuals without diabetes were included in this cross-sectional study. Liver lipids we

SUBMITTER: Tuomola N 

PROVIDER: S-EPMC12529492 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature