Burden of non-COVID-19 lower respiratory infections and etiologies in China and globally: An analysis for the global burden of disease study 2021.

ABSTRACT:

Background

Non-COVID-19 lower respiratory infections (LRIs) represent a persistent public health concern in China and globally. However, comprehensive assessments of their long-term spatiotemporal trends remain limited. This study aimed to quantify the burden of LRIs by age, sex, and geographic region across China and globally from 1990 to 2021.

Methods

Using standardized methodologies from the Global Burden of Disease Study 2021, we estimated LRI incidence and mortality globally and across 33 provincial-level units in China by sex, age, and year. Attributable incidence and mortality were further analyzed by underlying etiologies and risk factors, with corresponding 95 % uncertainty intervals.

Results

In 2021, LRI accounted for 343.6 (95% UI: 325.2-363.5) million epis

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12529499 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature