Genomic characterization of the T-cell receptor loci in <i>Ambystoma mexicanum</i>.

ABSTRACT:

Background

Amphibians are valuable models for comparative immunology. In the caudate Ambystoma mexicanum, the architecture of immunoglobulin loci resembles that of the anuran Xenopus tropicalis, although some antibody gene features are absent. Evidence supports the presence of T lymphocytes in axolotl, the expression of T cell receptor alpha, beta, and delta chains, and a restricted diversity in the delta chain. Here, we describe the T cell receptor loci in the A. mexicanum genome and compare them with X. tropicalis and other tetrapods.

Methods

T cell receptor loci were mapped and annotated in the A. mexicanum genome (UKY_AMEXF1_1) using reference sequences from axolotl, X. tropicalis, human, and mouse. Gene models were refined with

SUBMITTER: Pacheco-Olvera DL 

PROVIDER: S-EPMC12529555 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature