Score-based prediction model for female hepatocellular carcinoma surveillance in asymptotic HBsAg carriers: a multicenter cohort study in China.

ABSTRACT:

Background

Existing hepatocellular carcinoma (HCC) prediction models lack transferability and generalizability when applied to female populations, resulting in diminished performance and inadequate tools for accurate HCC risk stratification among females. This study aims to develop and validate a score-based prediction model for early detection of HCC in female hepatitis B surface antigen (HBsAg) carriers.

Methods

Participants were recruited from a multicenter prospective cohort engaged in liver cancer screening across China including seven high-risk rural areas and one additional high-risk rural area. The study involved 7080 females as the derivation cohort and 2069 as the validation cohort, with all participants aged 35-70 years and HBsAg positive. Laboratory tests and epi

SUBMITTER: Cao M 

PROVIDER: S-EPMC12529590 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature