BTEX chrono-metabolism and leukemogenic effects of night shift work in workers of gasoline stations: the EXPOSOWORK prospective panel study in Bulgaria.

ABSTRACT:

Background

Exposures to benzene, toluene, ethylbenzene and xylenes (BTEX) have been associated with impairment of the hematopoietic system, often leading to leukemogenesis. A prospective panel study: i) characterized the effect of night shift work (NSW) (12-hr night shift vs. 12-hr day shift) on urinary BTEX and metabolites in gasoline station workers in Plovdiv, Bulgaria, ii) evaluated the NSW effect on chrono-based BTEX genotoxic effects (as measured by 8-OHdG, a nonspecific biomarker of genotoxicity) including the influence of the downstream urinary metabolome.

Methods

During a week's working period, workers (n=71) followed both day shift and night shift work schedules (12-h long each shift) collecting four urine samples per worker (pre and end of shift). Airborne BTEX ex

SUBMITTER: Heibati B 

PROVIDER: S-EPMC12529599 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature