Whole genome sequencing reveals significant intra-hospital clonal transmission and a potential multidrug resistant and hypervirulent sequence cluster of <i>Corynebacterium striatum</i>.

ABSTRACT: With increasing reports about Corynebacteritum straitum, its role as an emerging human pathogen is been recognized. However, few studies have explored the genomic epidemiology of C. straitum in China. A total of 263 isolates collected in various specimens from 2021 to 2022 were analyzed from a tertiary hospital in China. Nearly all isolates (98.5%, 259/263) were multidrug resistant (MDR). The highest resistance was observed for clindamycin (96.5%), followed by ciprofloxacin (95.0%) and erythromycin (93.5%). Genome sequencing indicated a significant prevalence of intra-hospital clonal transmission, involving six distinct clones (clone one-six). An average of 7.35 antimicrobial resistance genes and 10.65 virulence genes were identified in each strain. Genomic analysis id

SUBMITTER: Zhou M 

PROVIDER: S-EPMC12529752 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature