Joint association of estimated glucose disposal rate and systemic inflammation response index with all-cause and cardiovascular mortality in patients with dyslipidemia: a nationwide prospective cohort study.

ABSTRACT:

Background

The relationship between estimated glucose disposal rate (eGDR), systemic inflammation response index (SIRI), and mortality in patients with dyslipidemia remains inconclusive. This study aimed to evaluate the independent and joint associations of eGDR and SIRI with all-cause and cardiovascular mortality.

Methods and results

This study included a total of 12,854 dyslipidemia patients from the National Health and Nutrition Examination Survey (1999-2018). Kaplan-Meier (KM) survival curves and weighted Cox regression analyses were performed to assess differences in mortality risk among different groups. Time-dependent ROC curves were used to assess predictive accuracy. The optimal cut-off values identified by maximally selected rank statistics method (MSRSM) were 7.84

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12529802 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature