Action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine: adenine pair triggered by MUTYH.

ABSTRACT:

Background

8-Oxo-7,8-dihydroguanine (8-hydroxyguanine, G^O) is a major damaged base caused by oxidation. Misincorporation of dATP opposite G^O by DNA polymerases leads to a G:C→T:A transversion at the damaged site via G^O:A intermediate formation. The G^O:A pair is also formed by 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate incorporation opposite A. The G^O:C and G^O:A pairs are both repaired through the base excision repair (BER) pathway to suppress the G:C→T:A mutations. G^O:C also induces action-at-a-distance mutations around the damaged base. These untargeted mutations seem to be induced through the excision of G^O from G^O:C by DNA glycosylases, such as OGG1 and NEIL1, in the BER p

SUBMITTER: Fukushima R 

PROVIDER: S-EPMC12529804 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature