A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility.

ABSTRACT:

Background

Polymorphisms in the XRCC3 gene, a key component of homologous recombination repair, have been studied for their potential role in thyroid cancer susceptibility. However, published findings remain inconsistent across populations and genetic variants. This meta-analysis aimed to clarify the associations between XRCC3 polymorphisms and thyroid cancer risk, with emphasis on variant- and ethnicity-specific effects.

Methods

A systematic search of PubMed, EMBASE, Scopus, CNKI, and other databases up to July 10, 2025 identified case-control studies reporting genotype distributions of XRCC3 polymorphisms in thyroid cancer. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under fixed- or random-effects models. Subgroup analyses by ethnicity, sens

SUBMITTER: Khosravi-Mashzi M 

PROVIDER: S-EPMC12529809 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature