Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis.

ABSTRACT:

Background

Alcoholic liver disease (ALD) is a key cause of chronic liver disease worldwide, which progresses to liver cirrhosis and even hepatocellular carcinoma. After years of application and research, the traditional Chinese medicine (TCM) Exocarpium Citri Grandis (ECG) has shown the significant function of lowering lipid and outering the effect of drinking, but the specific mechanism of its action in ALD is not clear.

Purpose

The aim of this study is to investigate the anti-alcohol and lipid-lowering effects of ECG and its underlying pharmacological mechanisms in vitro and in vivo.

Methods

First, this study initiated with a preliminary identification of the active components in the aqueous extract of ECG. Then zebrafish, mice, AML-12 cells and RAW264.7 cells were

SUBMITTER: Li YJ 

PROVIDER: S-EPMC12529825 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature