Caveolin-1 Is a Central Mediator of Acute Lung Injury in an Animal Model of Sickle Cell Disease.

ABSTRACT: Acute chest syndrome in sickle cell disease (SCD) carries high morbidity and mortality, with up to 15% of patients requiring invasive mechanical ventilation. However, the rates and mechanisms of ventilator-induced lung injury (VILI) in SCD remain poorly understood. We hypothesized individuals with SCD are protected from VILI in a caveolin-1 (Cav-1) dependent manner. SCD mice and control littermates underwent either spontaneous tidal breathing or high tidal volume mechanical ventilation for 4 h (VILI model), or received intratracheal Escherichia coli-derived lipopolysaccharide (LPS) or sterile phosphate-buffered saline and recovered for 16 h (LPS model). Bronchoalveolar lavage (BAL) samples were analyzed for inflammatory cytokine profiles and lung tissues were used for histology and

SUBMITTER: Prohaska CC 

PROVIDER: S-EPMC12529879 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature