Association of HbA1c/HDL-C ratio and depression with cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study.

ABSTRACT:

Background

Cardiometabolic multimorbidity (CMM)-the coexistence of two or more cardiometabolic diseases such as diabetes, heart disease, and stroke-poses serious health risks. Depression has recently been recognized as an independent risk factor for CMM. However, the role of the glycosylated hemoglobin A1c to high-density lipoprotein cholesterol ratio (HbA1c/HDL-C) in predicting CMM remains unclear. This study investigates the independent and combined effects of the HbA1c/HDL-C ratio and depression on CMM risk in middle-aged and older adults.

Methods

Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018, including 7,256 participants aged 45 and above. Kaplan-Meier analysis estimated cumulative CMM incidence. Multivariable Cox prop

SUBMITTER: Dong J 

PROVIDER: S-EPMC12529971 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature