Antinuclear Antibodies in Polycystic Ovary Syndrome: A Systematic Review of Observational Studies.

ABSTRACT: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in reproductive-age women, is characterized by menstrual irregularities and polycystic ovarian morphology. It is also associated with insulin resistance, chronic inflammation, and oxidative stress, all of which may promote autoimmunity. Several studies have suggested a higher occurrence of antinuclear antibodies (ANA) in PCOS but the main challenge in this field is the inconsistency of findings due to heterogeneous study designs and assay methods. However, to date, no systematic review has synthesized this evidence. We conducted a systematic review to evaluate the prevalence and serum levels of ANA in women with PCOS. A comprehensive search was performed in PubMed, Embase, and Scopus, and 13 studies were ultimately includ

SUBMITTER: Kwiatkowski J 

PROVIDER: S-EPMC12529972 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature