Modified Unipolar Return Pulsed Field Ablation in Ventricular Myocardium.

ABSTRACT:

Background

Various pulsed field ablation (PFA) parameters have been proposed to improve lesion depth. This study evaluated a modified unipolar return PFA system to create deep lesions in healthy and infarcted ventricular myocardia.

Methods

Numerical modeling was used to compare a modified unipolar return PFA system configuration with a conventional unipolar return (skin patch). We then performed ablation in 14 swine (5 with chronic myocardial infarction and 9 healthy). PFA lesions were created in the left ventricle using a focal catheter (4-mm tip) with a return electrode positioned in the inferior vena cava (biphasic, microsecond pulses of 1300 and 1500 V, 1-16 trains). Electroanatomical mapping guided ablation and lesion localization on magnetic resonance imaging were perf

SUBMITTER: Terricabras M 

PROVIDER: S-EPMC12529984 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature