Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

There are inconsistent reports regarding the effect of magnesium intake on blood pressure (BP) across hypertensive and normotensive populations.

Methods

We performed a meta-analysis and dose-response analysis to explore the relationship between magnesium supplementation and BP in randomized-controlled trials with a duration of ≥4 weeks, using a cubic spline regression model.

Results

Thirty-eight randomized controlled trials involving 2709 participants were eligible for inclusion. Studies included an elemental magnesium dose from 82.3 mg to 637 mg with a median dose of 365 mg and a median intervention period of 12 weeks. Mean differences of changes in BP were calculated by random effects meta-analysis. Magnesium intake resulted in a reduction in systolic BP

SUBMITTER: Argeros Z 

PROVIDER: S-EPMC12529988 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature