G-CSF Mediates Increased Renal Neutrophils and Kidney Damage in a Psoriasis Mouse Model.

ABSTRACT:

Background

Psoriasis is an autoimmune skin disease associated with increased incidence and severity of chronic kidney disease and hypertension. The mechanisms linking psoriasis skin inflammation with these comorbidities remain unclear.

Methods

We used flow cytometry, radiotelemetric blood pressure measurements, and histological and ELISA-based assessments of renal damage in mice with experimental psoriasis induced by keratinocyte-specific Tie2 overexpressing (KC-Tie2) and their littermate controls.

Results

Compared with littermate controls, KC-Tie2 mice with chronic skin inflammation developed albuminuria, histological evidence of glomerulosclerosis, and elevated blood pressure. KC-Tie2 mice had a selective and marked increase in circulating and renal neutrophi

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12529989 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature