Mild Hyperuricemia Attenuates Salt-Sensitive Hypertension and Kidney Damage.

ABSTRACT:

Background

Asymptomatic hyperuricemia is associated with poor outcomes in kidney and cardiovascular diseases, but its causative role remains controversial. Clinical studies have shown a positive correlation between increased dietary sodium intake and urinary uric acid excretion, suggesting that hyperuricemia may influence salt-sensitive hypertension and associated kidney damage.

Methods

To study the effects of mild hyperuricemia on salt-sensitive hypertension, male and female Dahl SS rats were fed a diet containing a uricase inhibitor (2% oxonic acid) and 4% NaCl (high salt) or a high salt-only diet for 3 weeks. Analyses were conducted using radiotelemetry, immunohistochemistry, and RNA-Sequencing.

Results

Uricase inhibition resulted in a ≈3.5-fold increase in plasma

SUBMITTER: Dissanayake LV 

PROVIDER: S-EPMC12529993 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature