Predicting the Dominant Role of Dense Aggregates in Magnetic Hyperthermia via Intracellular-Mimetic Nanoparticle Models.

ABSTRACT: Dense aggregation of magnetic nanoparticles (MNPs) in cellular environments is a major contributor to reduced magnetic hyperthermia (MH) efficiency; however, in situ magnetic characterization remains challenging, necessitating reliable extracellular models to predict such behavior. In this study, soft and dense aggregates (≈200 nm) are engineered using 10 nm iron oxide MNPs, encapsulated in polymeric (soft) or inorganic (dense) shells, with morphological features and strong magnetic dipolar interactions confirming their similarity to nanoparticle assemblies found in living cells. Unlike previous studies that induced aggregation by modifying the surrounding medium, the approach enables controlled, invariant aggregation states, allowing systematic evaluation of the transition from soft to de

SUBMITTER: Garcia-Acevedo P 

PROVIDER: S-EPMC12530015 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature