Porous Silicon Nanoparticle Hydrogel Formulation for Topical Delivery of Flightless I Neutralizing Antibody and Improved Diabetic Wound Healing.

ABSTRACT: Diabetes-related foot ulcers (DRFUs), affecting one-third of individuals with diabetes, are a leading cause of hospitalization. Current treatment options to expedite healing are limited, with the effectiveness of potential therapeutics reduced by the hostile environment inherent to most diabetes-related wounds. Topical delivery vehicles that protect drugs from the protease-enriched wound environment, whilst displaying a slow-release profile, are needed to facilitate wound closure. Biodegradable porous silicon nanoparticles (pSi NPs) in a thermo-sensitive hydrogel formulation are assessed for the delivery of the wound healing therapeutic Flightless I neutralizing antibody (FnAb). FnAb is loaded into pSi NPs at clinically relevant doses and achieves functional antibody release over 14 days.

SUBMITTER: Turner CT 

PROVIDER: S-EPMC12530027 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature