Restarting Oral Anticoagulation in Patients With Atrial Fibrillation After Admission for a Gastrointestinal Bleeding Event: Effectiveness and Safety of Direct Oral Anticoagulants Compared to Warfarin.

ABSTRACT:

Background

There are sparse data to guide resumption of direct oral anticoagulants (DOACs) versus warfarin in patients with atrial fibrillation (AF) who survive a major gastrointestinal bleeding (GIB) event.

Objective

To compare the risk-benefit profile of restarting DOACs versus warfarin among patients with AF following hospitalization for major GIB.

Methods

Using claims submitted to a commercial health insurance database from January 2010 to December 2017, we identified adult patients with AF hospitalized for a major GIB while receiving oral anticoagulants. Eligible patients were required to have survived and restarted oral anticoagulation with DOACs or warfarin within 90 days following hospital discharge for major GIB. The outcomes of interest were subsequent hospi

SUBMITTER: Lawal OD 

PROVIDER: S-EPMC12530032 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature