Dynamic Liposome Sensing Platform to Wirelessly Ensure Nucleic Acid Encapsulation via Non-Contact Perception.

ABSTRACT: The demand for a high-throughput and noncontact monitoring system to guarantee the payload of nucleic acid in liposomes is rapidly increasing for raising efficiency in gene therapeutics. Herein, inspired by electroreceptors of elasmobranch fishes, a dynamic liposome sensing (DLs) platform is developed by implementing the electret layer (CYTOP)-coated single-walled carbon nanotube-based thin film transistor (eSWCNT-TFT) which can monitor differences of the net-charge on deoxyribonucleic acid (DNA)-loaded liposomes. The SWCNT-TFTs are roll-to-roll (R2R) printed on plastic film and then, simply laminated by the droplet microfluidic chip to optimize the aqueous droplet lengths by controlling a ratio of injecting speed between oil to aqueous solution. The buffer solution, DNA-free liposomes, an

SUBMITTER: Jung Y 

PROVIDER: S-EPMC12530037 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature