A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness.

ABSTRACT: TRPM1 channels, regulated by mGluR6 at the dendrites of retinal ON bipolar cells (BCs), play a crucial role in visual signal transduction. Both Trpm1 knockout (KO) and mGluR6 KO mice are models of congenital stationary night blindness with grossly normal morphology. However, robust pathological spontaneous oscillations in retinal ganglion cells (RGCs) have been observed in Trpm1 KO retinas but not in mGluR6 KO retinas. We investigated the mechanism underlying these oscillations in the Trpm1 KO retina using whole-cell clamp techniques. We found that inhibitory and excitatory synaptic inputs produced anti-phase oscillations in OFF and ON RGCs, respectively, and that oscillations could be suppressed by blockers targeting the AII amacrine cell (AC) pathway. The rd1 retina, a model for retiniti

SUBMITTER: Horie S 

PROVIDER: S-EPMC12530179 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature