Metabolic profile alterations in juvenile rats with bladder overactivity induced by short-term high-fructose intake.

ABSTRACT:

Background

Overactive bladder syndrome (OAB) is a common condition that affects both adults and children, often causing significant discomfort and negatively impacting quality of life. This study aimed to preliminarily evaluate whether fructose exposure induces OAB-like symptoms in juvenile rats and to explore potential metabolic mechanisms involved.

Methods

Three-week-old female Sprague-Dawley rats were randomly assigned to two groups: a model group fed a 60% fructose diet for one week, and a control group fed a standard diet. Body weight, blood biochemical parameters, urination behavior, and urodynamic function were assessed. Bladder tissue was analyzed using hematoxylin and eosin staining, immunohistochemistry, and immunofluorescence. Molecular and metabolic changes were

SUBMITTER: Cui X 

PROVIDER: S-EPMC12530204 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature