Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis.

ABSTRACT:

Objectives

To evaluate the clinical applicability of autoantibodies (AAbs) measured by ELISA against the angiotensin II type 1 receptor (AT₁R) and endothelin-1 type A receptor (ET_AR) in systemic sclerosis (SSc) patients.

Methods

Serum samples from n=279 SSc patients from the Leiden Systemic Sclerosis cohort, n=42 patients with primary Raynaud's phenomenon, n=24 patients with rheumatoid arthritis and n=20 healthy controls were tested for anti-AT₁R- and anti-ET_AR AAbs. Levels were compared between groups with Mann-Whitney U tests or Kruskal-Wallis tests. Risk ratios and Kaplan-Meier analyses were used to determine associations between AAbs and disease manifestations or all-cause mortality. Analyses were repeated in an independent coh

SUBMITTER: van der Wouden KE 

PROVIDER: S-EPMC12530366 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature