Association between the triglyceride-glucose index and hyperuricemia: potential role of obesity in patients with Type 2 diabetes mellitus.

ABSTRACT:

Background

The triglyceride-glucose (TyG) index has recently emerged as a simple surrogate marker of insulin resistance. However, the relationships among the TyG index, obesity, and hyperuricemia in individuals with T2DM remain unclear. This study investigates the associations of the TyG index and obesity with hyperuricemia in T2DM, and the possible role of obesity in these associations.

Methods

In this cross-sectional study, 1,159 adults with T2DM were enrolled. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. Participants were stratified into hyperuricemia and non-hyperuricemia groups based on serum uric acid levels. Multivariable logistic regression and subgroup analyses were performed to assess the association between

SUBMITTER: Tang D 

PROVIDER: S-EPMC12530394 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature