Cardiorespiratory fitness in children with overweight/obesity: Insights into the molecular mechanisms.

ABSTRACT:

Objectives

High cardiorespiratory fitness (CRF) levels reduce the risk of developing cardiovascular disease (CVD) during adulthood. However, little is known about the molecular mechanisms underlying the health benefits of high CRF levels at the early stage of life. This study aimed to analyze the whole-blood transcriptome profile of fit children with overweight/obesity (OW/OB) compared to unfit children with OW/OB.

Design

27 children with OW/OB (10.14 ± 1.3 years, 59% boys) from the ActiveBrains project were evaluated. VO₂ peak was assessed using a gas analyzer, and participants were categorized into fit or unfit according to the CVD risk-related cut-points. Whole-blood transcriptome profile (RNA sequencing) was analyzed. Differential gene expression analysis was

SUBMITTER: Plaza-Florido A 

PROVIDER: S-EPMC12530440 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature