Comparative Effectiveness and Safety of Adalimumab, Secukinumab, and Upadacitinib in Psoriatic Arthritis: A Prospective Cohort Study Based on PARWCH Cohort.

ABSTRACT: Psoriatic arthritis (PsA) is a chronic inflammatory disease, with prevalence among psoriasis patients ranging from 6% to 42% across populations. Although targeted therapies such as adalimumab (ADA), secukinumab (SEC), and upadacitinib (UPA) have demonstrated efficacy in randomized controlled trials, real-world head-to-head comparisons remain limited. This study aimed to compare the real-world effectiveness and safety of ADA, SEC, and UPA in PsA patients. We conducted a prospective cohort study using data from the PARWCH database. PsA patients treated with ADA, SEC, or UPA were included and followed at baseline, Week 4, Week 12, and Week 24. Skin responses were evaluated using PASI75/90. Joint outcomes-including peripheral and axial arthritis-were assessed with ACR, PsARC, and ASAS criteria

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12530465 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature