Identification of genes that differentiate Mannheimia haemolytica genotypes 1 and 2 using a pangenome approach.

ABSTRACT: Mannheimia haemolytica is an opportunistic bacterial pathogen associated with the economically costly bovine respiratory disease. Two genotypes have been described, of which genotype 2 is more strongly associated with disease. Several previous studies have investigated the genomic differences between the genotypes and/or the major serotypes (1, 2 and 6) of M. haemolytica, however we still lack a clear basis for the greater disease association of genotype 2 (serotypes 1 and 6) and demonstrations of phenotypic differences are scarce. This work builds upon previous investigations to identify genes that differentiate the two genotypes with a particular focus on genes that may play a role in virulence and fitness in the respiratory tract microbiome. We identified 422 genotype differentiating ge

SUBMITTER: Deschner D 

PROVIDER: S-EPMC12530517 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature