Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniens.

ABSTRACT: The prefrontal-hippocampal-entorhinal system is perhaps the most widely-studied circuit in cognitive and systems neuroscience, due to its role in supporting cognitive functions such as working memory and decision-making. Disrupted communication within this circuit is a key feature of disorders such as schizophrenia and dementia. Nucleus reuniens (NRe) is a midline thalamic nucleus that sits at the nexus of this circuit, linking these regions together. As there are no direct projections from prefrontal cortex to hippocampus (HPC), the accepted model is that the NRe mediates prefrontal drive of hippocampal activity, although these connections are poorly defined at the cellular and synaptic level. Using ex vivo optogenetics and electrophysiology in both mice and rats, alongside monosynaptic c

SUBMITTER: Andrianova L 

PROVIDER: S-EPMC12530533 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature