Development and validation of a nomogram for all-cause mortality in osteoporosis patients over five years.

ABSTRACT:

Purpose

Osteoporosis significantly increases fracture risk and mortality, yet robust tools for predicting long-term mortality in this population are lacking.This study aimed to develop and validate a nomogram for predicting 5-year all-cause mortality among patients with osteoporosis.

Methods

A retrospective cohort study was conducted using data from 2,165 osteoporosis patients sourced from the NHANES database (2007-2023; training set) and 304 patients from Dandong Central Hospital (2017-2024; validation set). Potential risk factors were analyzed through LASSO regression, followed by multivariate logistic regression, to identify independent predictors.A nomogram was constructed employing significant predictors. Finally, the C-index, ROC curve, calibration curve, and decision

SUBMITTER: Li Y 

PROVIDER: S-EPMC12530536 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature