Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses.

ABSTRACT: Dysfunction of the basal ganglia is implicated in a wide range of neurological and psychiatric disorders. Our understanding of the operation of the basal ganglia is largely derived on data from studies conducted on mice, which are frequently used as model organisms for various clinical conditions. The striatum, the largest compartment of the basal ganglia, consists of 90-95% striatal projection neurons (SPNs). It is therefore crucial to establish if human and mouse SPNs have distinct or similar properties, as this has implications for the relevance of mouse models for understanding the human striatum. To address this, we compared the general organization of the somato-dendritic tree of SPNs, the dimensions of the dendrites, the density and size of spines (spine surface area), and ion chann

SUBMITTER: Kozlov A 

PROVIDER: S-EPMC12530558 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature