IGF2BP2 contributes to thyroid cancer progression by enhancing the stability of m6A-modified CTSH mRNA.

ABSTRACT:

Background

N6-methyladenosine (m6A) is a prevalent RNA modification in eukaryotes that regulates RNA stability and translation. Dysregulated m6A modification is implicated in cancer progression. This study investigated the role of the m6A reader protein, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 BP2), in the progression of thyroid cancer (TC).

Methods

Cell proliferation was assessed using cell counting kit-8 (CCK8) and 5-ethynyl-2'-deoxyuridine (EdU) assays. Cell migration and invasion were evaluated by Transwell assays. A xenograft tumor model was employed to examine the impact of IGF2 BP2 on tumor growth in vivo. Gene functional annotation was performed through GO analysis. Spearman correlation analysis was utilized to evaluate the relationship between the

SUBMITTER: Dong L 

PROVIDER: S-EPMC12530564 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature