The association between serum lipid levels and colorectal cancer risk: A dose-response meta-analysis of 23 studies.

ABSTRACT:

Background

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and the second leading cause of cancer-related mortality. Based on recent studies, lipid levels may have a relationship with the risk of CRC. This meta-analysis aims to better understand the association between various serum lipids and CRC risk.

Methods

A comprehensive search was conducted in Web of Science, PubMed, and Scopus. This meta-analysis, including only prospective cohort studies, performed random-effects meta-analyses using the Restricted Maximum Likelihood (REML) model to assess the association between the highest versus lowest categories of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoproteins (LDL) with the risk of CRC, pr

SUBMITTER: Vahed IE 

PROVIDER: S-EPMC12530605 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature