Exploring the role of routine brain imaging in detecting asymptomatic brain metastases in first diagnosed HER2-positive breast cancer.

ABSTRACT:

Background

HER2-positive breast cancer is leading to aggressive tumor growth and a higher risk of metastasis, particularly to the central nervous system (CNS). Routine brain imaging for asymptomatic HER2-positive patients is debated, with no current consensus; Given the severe clinical implications of brain metastases, further research is needed to determine the cost-effectiveness and clinical utility of routine imaging for high-risk patients to improve outcomes and inform targeted screening protocols.

Methods

This retrospective, monocentric study at the General Hospital of Vienna (AKH Wien) examined female HER2-positive breast cancer patients at first diagnosis to assess brain metastasis from January 2019 to February 2024. The study included patients with asymptomatic confi

SUBMITTER: Leser C 

PROVIDER: S-EPMC12530607 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature