Influence of age and antiepileptic comedication on lacosamide concentrations in children with epilepsy: A retrospective cohort study.

ABSTRACT:

Object

To explore the influencing factors of lacosamide serum concentration in children with epilepsy, and to provide evidence-based guidance for individualized dosing strategies.

Methods

Clinical data of pediatric epilepsy patients treated with lacosamide from September 2021 to January 2025 were retrospectively analyzed. Participants were stratified by age into ≤6, 6-12, and >12 years groups. Non-parametric tests were employed to compare differences in daily dose, weight-adjusted daily dose, serum concentration, and concentration-to-dose ratio (CDR) across sex, age, and concomitant antiepileptic drugs (AEDs) groups. Multiple linear regression analysis was conducted to identify independent factors influencing serum concentration.

Results

The study enrolled 438 patient

SUBMITTER: Du Z 

PROVIDER: S-EPMC12530613 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature