Hemolysis Induced by Pulsed-Field Ablation of Atrial Arrhythmias: A Comparative Analysis of Current Systems.

ABSTRACT:

Introduction

Pulsed-field ablation (PFA) is an emerging technology associated with dose-dependent hemolysis as a recently recognized side effect. This study aimed to compare hemolysis levels and assess dose-dependency across three PFA systems: a pentaspline catheter (PSC), a lattice-tip focal catheter (LTFC), and a variable loop circular catheter (VLCC).

Methods

Patients treated for atrial arrhythmias with the LTFC (n = 29) or the VLCC (n = 30) were included from a prospective registry. A matched cohort of patients treated with the PSC (n = 28) was recruited from the same registry. Creatinine levels and markers of hemolysis were measured pre-ablation and 1 day postablation.

Results

Haptoglobin levels decreased significantly more with the PSC and VLCC compared to the L

SUBMITTER: Bruss J 

PROVIDER: S-EPMC12530677 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature