A New Polymer-Coated Xenogeneic Extracellular Matrix to Prevent Postoperative Adhesion Readily Applicable in the Clinic.

ABSTRACT: Post-neurosurgical dura reconstruction is crucial for preventing CSF leakage and reducing infection risk. When primary closure is not possible, synthetic and semisynthetic dura substitutes are commonly used, but postoperative adhesions remain a major complication, particularly in reoperations for brain tumors and spinal surgeries. To address this, the use of initiated chemical vapor deposition (iCVD) is investigated to create a polymer-coated dura substitute that minimizes adhesions. iCVD, a dry, solvent-free technique, enables uniform polymer film deposition at low temperatures, ensuring biocompatibility and purity. A widely used dura substitute (Lyoplant) is coated with three biocompatible polymers (pHEMA, EGDMA, V4D4) and assessed cytotoxicity using fibroblasts. Adhesion levels are comp

SUBMITTER: Kim KH 

PROVIDER: S-EPMC12530699 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature