Electrohydrodynamic Jetting of Mucoadhesive Protein Nanoparticles as a Chemopreventive Strategy for Oral Squamous Cell Carcinoma.

ABSTRACT: Intraepithelial delivery of cancer preventive therapies for oral squamous cell carcinoma (OSCC) has been limited by factors such as rapid mucus turnover, enzymatic degradation, and salivary clearance. These challenges, coupled with poor solubility and associated low bioavailability, have hampered clinical progress. To address these challenges, we present an effective method for encapsulation and sustained release of poorly soluble, apolar therapeutics via mucoadhesive protein nanoparticles (PNPs). To demonstrate feasibility, PNPs loaded with N-(4-hydroxyphenyl) retinamide (4HPR, fenretinide), a hydrophobic chemopreventive compound with low solubility were produced via a three-step process: 1) high-pressure homogenization to solubilize and stabilize 4HPR via association with human serum alb

SUBMITTER: Chang A 

PROVIDER: S-EPMC12530700 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature