Amphiphilic Poly(γ-glutamic acid) Derivatives for Delivering Doxorubicin in Cancer Cells.

ABSTRACT: One of the most limiting factors in cancer treatment is the difficulty of delivering anticancer agents effectively to tumor sites. To overcome this challenge, this research focuses on developing a carrier that has been modified to possess amphiphilic properties while remaining biodegradable and biocompatible. Amphiphilic esters derived from poly(γ-glutamic acid) by modifying the carboxylate side groups with 4-phenyl-butyl bromide were prepared. These copolymers self-assembled into nanoparticles via nanoprecipitation. The cytocompatibility of the nanoparticles was assessed through lactate dehydrogenase release and metabolic activity of U-87 glioma cells. Fluorescein isothiocyanate labeling demonstrated effective cellular uptake of nanoparticles. These nanoparticles were further decorated wi

SUBMITTER: Dorost P 

PROVIDER: S-EPMC12530701 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature