IPSC-derived MSCs alleviate arthritis in collagen-induced arthritis mice by reducing synovial CD86h  iIL1βhi macrophage.

ABSTRACT:

Background

Joint bone destruction in rheumatoid arthritis (RA) leads to poor prognosis, with current treatments mainly targeting inflammation and limited focus on bone damage. Mesenchymal stem cells (MSCs) offer anti-inflammatory and bone repair properties, but their clinical application is hindered by cellular heterogeneity. Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) present a promising alternative due to their lower heterogeneity and replicative senescence, although their potential in RA treatment remains underexplored.

Methods

iMSCs were injected intraarticularly in a collagen-induced arthritis (CIA) model. Treatment outcomes, including plantar swelling, joint score, histological and immunohistochemical staining, microCT imaging, and bone loss, w

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12530881 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature