Dietary Sodium Humate Improves Intestinal Mucosal Immune and Biological Barriers of Genetically Improved Farmed Tilapia (<i>Oreochromis niloticus</i>).

ABSTRACT: The present research examined the impact of sodium humate (SH) in feed on the intestinal health of genetically improved farmed tilapia (GIFT, Oreochromis niloticus). GIFT with average weight of 3.9 g were provided with diets incorporated diverse content of SH from low to high (0%, 0.1%, 0.2%, 0.4%, and 0.6%, denoted as SH0, SH1, SH2, SH4, and SH6) for 63 days. Results indicated that incorporating 0.4%-0.6% SH into the diet significantly reduced the plasma lactulose/rhamnose ratio, while plasma diamine oxidase (DAO) activity was depressed by supplementation with 0.1%-0.4% SH (p < 0.05). Dietary SH level increased the length and width of villu, as well as the levels of polymeric immunoglobulin receptor in the distal intestine (DI). The SH2 group exhibited elevated levels of int

SUBMITTER: Huang B 

PROVIDER: S-EPMC12530943 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature