A recessive coat color dilution in Dexter cattle attributed to a missense mutation in SLC45A2.

ABSTRACT: Three colors of Dexter cattle are currently recognized: black, red, and dun. In Dexters, dun is determined by a recessive genotype of TYRP1 (b/b) that dilutes an otherwise black animal (MC1R genotype ED/-); this variant does not impact red cattle. A subset of Dexters with dilute coat colors described as dark dun/chocolate (CD) or light dun/cream (CL) were identified. Although phenotypically similar to dun, they did not have the expected TYRP1 b/b genotype. Given relationships among the reported individuals, we hypothesized that a novel recessive genotype is causative of CD on a black background and CL on a red background. Whole-genome sequence was generated from four dilute Dexters (three CD and one CL), and one black calf of a CD dam. None of the cattle sequenced had the TYRP1 b/b genotyp

SUBMITTER: Fuller AM 

PROVIDER: S-EPMC12530945 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature