Development and validation of a predictive model for severe radiation-induced esophagitis in lung cancer patients undergoing moderate hypofractionated radiotherapy.

ABSTRACT:

Background and objectives

Moderate hypofractionated radiotherapy (MHRT) is an important treatment modality for lung cancer, offering shorter courses and improved local control, yet it also markedly increases the risk of severe radiation-induced esophagitis (RIE; grade ≥3). Severe RIE compromises quality of life and adherence to therapy and may necessitate interruption of radiotherapy. This study aimed to develop a prediction model based on clinical and dosimetric factors to identify high-risk patients receiving MHRT and to facilitate individualized treatment strategies.

Methods

Lung cancer patients receiving moderate hypofractionated radiotherapy were included, with the endpoint defined as grade ≥3 radiation-induced esophagitis. Baseline characteristics were summarized using

SUBMITTER: Zhang A 

PROVIDER: S-EPMC12531044 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature