Association between fentanyl use and reduced risk of tension pneumothorax in extremely preterm infants born at 22-23 weeks' gestation: a retrospective case-control study.

ABSTRACT:

Background

Tension pneumothorax is a life-threatening complication in extremely preterm infants, especially within the first 72 hours of life. Identifying preventive strategies is crucial to improving survival rates. This study aimed to evaluate the association between fentanyl use and the incidence of tension pneumothorax in extremely preterm infants born at 22-23 weeks of gestation.

Methods

This retrospective case-control study was conducted at a tertiary care center in Japan. It included 138 preterm infants with a gestational age from 22 weeks + 0 days to 23 weeks + 6 days (January 2010 to March 2023). Logistic regression and propensity score matching were used to adjust for confounding factors such as chorioamnionitis stage 2-3, oligohydramnios, antenatal steroids, venti

SUBMITTER: Kurimoto T 

PROVIDER: S-EPMC12531072 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature