Comparative analysis of short-term and long-term LL-37-induced rosacea-like mouse models: Histopathological features and inflammatory immune responses.

ABSTRACT:

Background

It is well recognized that developing new animal models, refining the existing mouse models, and thoroughly characterizing their features are essential for gaining a deeper understanding of rosacea pathogenesis and for advancing therapeutic strategies in this direction. Accordingly, we aimed to characterize the pathological features of a long-term LL-37-induced mouse model of rosacea and to compare the disease manifestations and pathophysiological characteristics between short-term and long-term LL-37-induced models. A key focus was to investigate differential gene expression and the underlying mechanisms of immune system dysregulation in these models.

Methods

We comparatively assessed skin lesion manifestations, the extent of inflammatory infiltration, sebaceous

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12531105 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature